BDBM50063917 (2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N(1),2-dihydroxy-3-(2-methylpropyl)butanediamide::CHEMBL279785::cid_119031::marimastat

SMILES CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C

InChI Key InChIKey=OCSMOTCMPXTDND-OUAUKWLOSA-N

Data  15 KI  104 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50063917   

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi:  0.700nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of recombinant human matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of Recombinant human matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  2nMAssay Description:Activity against Matrix metalloproteinase-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibitory activity against matrix metalloproteinase 1 isolated from the culture medium of human skin fibroblasts induced with PMAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against MMP-1 (Matrix metalloproteinase-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of HFC MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  0.780nMAssay Description:In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of full length human recombinant MMP1 using MCA-Arg-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-Glu-Arg-NH2 as substrate preincubated for 60 mins followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  5nMAssay Description:50% inhibition of human recombinant fibroblast collagenase (MMP-1, HFC)More data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  2.90nMAssay Description:50 percent inhibition of human Matrix metalloprotease-1 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  2.90nMAssay Description:Inhibitory activity against human Matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank